Cristiano Ronaldo and Dimitar Berbatov could start up front for Manchester United against Chelsea on Sunday.
Berbatov has recovered from a knee injury, while Ronaldo made his comeback from ankle surgery as a substitute in the 0-0 draw with Villareal.
Chelsea defender John Terry is available for the match after a successful appeal against a red card.
But Blues manager Luiz Felipe Scolari has said striker Didier Drogba is still not fit enough to play for 90 minutes.
With uncertainty over the Ivory Coast international's fitness, Scolari could be tempted to name the same starting XI that has beaten Manchester City and Bordeaux in the past week.
Ferguson revealed Ronaldo is desperate to feature at Stamford Bridge following a 30-minute appearance in the 0-0 draw with Villareal on Wednesday, his first appearance since the Champions League final in May.
"Cristiano is nibbling in my ear all the time. He is bursting to play," said the Scot.
"The boy was on fire on Wednesday. He was revved up to do really well.
"When you think he has had an operation, has been in rehab for two months and had not played since May 21. It was a big ask for him.
"But you have to say his performance level was outstanding. He has trained very well and is a natural athlete, so I have no qualms on that score. I just have to decide whether it is the right time."
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Man Utd: Van der Sar, Neville, Ferdinand, Evans, Evra, Nani, Hargreaves, Fletcher, Park, Rooney, Tevez. Subs: Foster, Brown, Ronaldo, Anderson, Giggs, Vidic, O'Shea.
Villarreal: Diego Lopez, Angel, Rodriguez, Godin, Capdevila, Cani, Eguren, Edmilson, Pires, Fernandez, Franco. Subs: Viera, Santi Cazorla, Ibagaza, Llorente, Javi Venta, Senna, Fuentes. Referee: Wolfgang Stark
Liverpool duo Steven Gerrard and Fernando Torres have both been declared fit to face Manchester United.
Gerrard missed England's 4-1 win in Croatia on Wednesday after undergoing a minor groin operation, while Torres has recovered from a hamstring tear.
Dimitar Berbatov is set to make his Man Utd debut after signing from Tottenham for £30.75m on transfer deadline day.
Owen Hargreaves (tendinitis) and Michael Carrick (ankle) both return for the trip to Anfield.
The news that Gerrard and Torres are in line to face United will be a big boost for Liverpool.
Rafael Benitez is desperate to beat Man Utd
Manchester United manager Sir Alex Ferguson says he is not concerned about the threat posed by newly wealthy neighbours Manchester City.
City's prospective new Arab owners have set their sights on winning the Premier League title and the Champions League.
"I can't be worried," said Ferguson. "There's always challenges in football.
"Some years ago it was Chelsea, some years ago it was Arsenal. Wherever the challenges come you just have to accept it. It doesn't change anything."
The Abu Dhabi United Group funded City's stunning capture of Brazilian forward Robinho from Real Madrid for a British record fee of £32.5m on transfer deadline day.
That came after they had failed in a bid to hijack United's purchase of Tottenham striker Dimitar Berbatov.